4:30 PM ET
Buffalo Bills at Washington Redskins
Reason to Watch: Robert Griffin III wants to play. James Andrews doesn't want him to. Or does. Mike Shanahan doesn't want him to play. Or does. Who knows anything at this point.
7:00 PM ET
Cleveland Browns at Indianapolis Colts
Reason to Watch: Cause I don't think the Browns are going to be awful this year. Maybe watchable. This is a good test of watchable. Also, Andrew Luck is fun to watch.
10:00 PM ET
San Diego Chargers at Arizona Cardinals
Reason to Watch: If the Chargers lose to the Cardinals, there may be more cause to worry in San Diego. Or the Cardinals might not be bad. We won't know anything until week 1, anyway.
This is your Open Thread for the day/night's festivities. As always, Open Thread Responsibly (TM).