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The second set of games features an NFC West showdown, a Super Bowl rematch, and the Chiefs and the Dolphins, which the Chiefs will enter without Jamaal Charles.
San Francisco 49ers at Arizona Cardinals
4:05 PM ET / 3:05 PM CT
Denver Broncos at Seattle Seahawks
4:25 PM ET / 3:25 PM CT
Kansas City Chiefs at Seattle Seahawks
4:25 PM ET / 3:25 PM CT
As always, Open Thread Responsibly (TM).